Normal BER types transient single-strand breaks, so it is comprehensible that BER enzymes play an essential position in single-strand break repair.

The manufacturing of heat-shock proteins (HSPs - cellular safety from thermal and other stresses) may be increased by a transient elevation of temperatures that would ordinarily kill a cell. Removal of purine or pyrimidine bases from DNA (depurination and depyrimidation ) is commonly caused by hydrolysis or thermal disruption. PCNA, RFC and a polymerase create a "flap" of nucleotides which might be removed by FEN1 (Flap ENdonuclease−1); Deamination of cytosine by hydrolysis is an example of DNA damage repaired by quick-patch BER.
Adenine and Guanine are known as purines, whereas Thymine and Cytosine are pyrimidines. Glycosylase (glycosidase) enzymes remove individually damaged nucleic acid bases (purines or pyrimidines) from the deoxyribose sugars to which they're hooked up. The phosphate-linked sugars related to the bases form a single strand of DNA, which pairs with an antiparallel strand of 3',5'−phosphodiester bonds to kind the DNA double-helix.

A specific sequence of 3 bases in DNA will trigger the selection of a single amino acid for protein synthesis.

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